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In addition, the use of bacteria as carriers to deliver drugs to tumors and other lesions, or to modify bacteria to express or deliver targeted drugs will greatly improve the therapeutic effect (39, 45, 46)

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Individuals with defects of methylmalonyl CoA mutase or polymorphisms occurring in the genes that code for enzymes in the cobalamin adenosylation pathway, may also have low serum vitamin B12 levels (Kano et al., 1985)