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Amir et al., MECP2 is an X-linked gene and most affected patients are females, who present stereotypies, motor capability regression and cognitive impairments that reflect in post-mortem brain tissue by reduced dendritic complexity and reduced spine densities in the hippocampus and across all layers of the cortex (Belichenko et al., MECP2 mutations, and their phenotypic severity depends on the type of mutation or the pattern of somatic X-chromosome inactivation in the patient (Chahrour and Zoghbi, Mecp2 knockouts (Belichenko et al., Since Rett syndrome manifests itself in early postnatal life when experience shapes neuronal circuit wiring, and since Mecp2 is activity-dependently regulated (Cohen et al., Mecp2 might mediate experience-dependent processes of synapse development