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Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites

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Notch1 is upregulated in CYP-treated rats and promotes microglial activation and neuroinflammation, mediating mechanical allodynia associated with CYP-induced cystitis and decreasing pain thresholds, ultimately contributing to pelvic pain in interstitial cystitis/bladder pain syndrome (IC/BPS)