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Acknowledgements Cryo-EM data were collected at the University of Texas Southwestern Medical Center (UTSW) Cryo-Electron Microscopy Facility, funded in part by the Cancer Prevention and Research Institute of Texas (CPRIT) Core Facility Support Award RP170644

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Program:12 Week Prgoram

Meanwhile, despite three serious adverse events identified in two patients, no dose-limiting toxicities were observed