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Pober and Sessa, 2007) or binding of pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) to pattern recognition receptors (PRRs) on the endothelial surface ( FIGURE 3 First, endothelial permeability acutely increases due to formation of focal endothelial gaps, allowing heightened extravasation of plasma and leukocytes (McDonald, 2001)

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doi: 10.1182/blood-2006-10-048215 91 KleimanAHübnerSRodriguez ParkitnaJMNeumannAHoferSWeigandMAet al