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Fork head box O transcription factor 4-D-Retro Inverso (FOXO4-DRI), a synthetic isoform of the transcription factor FOXO4, triggers apoptosis of senescent cells by disrupting the interaction between FOXO4 and p53 and releasing p53 into the cytosol

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doi: 10.1158/1940-6207.CAPR-08-0160