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[DOI] [PMC free article] [PubMed] [Google Scholar] 518.McMillin DW, Negri JM, Mitsiades CS

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Even metformin (metf), the US Food and Drug Administration’s (FDA) recommended front-line medicine for DM (44), is devoid of contraindications (45, 46), yet it fails to exert its therapeutic effect due to patient noncompliance (47)