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Let me break down exactly what you must know to answer this question thoroughly… What You Need to Know BPC-157 has a very short plasma half-life (minutes to hours), but its biological effects last significantly longer Half-life measures how quickly a compound clears your bloodstream, while duration of action describes how long it continues working BPC-157 triggers cascading biological processes that continue long after the peptide itself is metabolized Once or twice daily dosing is typically sufficient for most therapeutic applications How Long BPC-157 Stays in Your System Most people hear “short half-life” and immediately think “needs frequent dosing.” That’s a fundamental misunderstanding of the pharmacology involved with BPC-157 from the time it enters your body to the time it leaves