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A phase 3 bardoxolone methyl evaluation in patients with chronic kidney disease and T2DM (BEACON) trial (NCT01611569) in 2185 patients with T2DM and stage 4 chronic kidney disease showed that BAR transiently increased eGFR and reduced urine albumin-to-creatinine ratio

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For epileptic behavior analysis, histopathological quantification, oxidative stress biomarkers, and RT-qPCR data, the analysis involved one-way ANOVA with Tukey’s test as a post hoc assessment