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Repeating the plaque assays, it was observed that complementation with constitutively expressed 3FLAG-TgUAE1 WT restored plaque formation in cKD-TgUAE1 parasites cultured in the presence of ATc ( Fig

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It becomes particularly useful when the phenotype suggests undermethylation, there is an unusual response to folate or methyl donors, whole-blood histamine suggests a Walsh methylation pattern, or the clinical picture raises the possibility of an epigenetic driver