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This leads to the release of the signaling molecule cytochrome C and activation of caspase, which subsequently activates the polymerase via hydrolysis, leading to apoptosis

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In addition, heme iron can also participate in lipoprotein oxidation and lipid peroxidation end-products formation, such as MDA, 4-HNE, oxysterols, and aldehyde during meat storage, processing, and digestion [56]