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The Medical Subject Heading (MeSH) and keywords used were: “D-dimer”, “thrombosis”, “venous thromboembolism”, “pulmonary embolism”, “deep vein thrombosis”, “cancer”, “management”, “treatment”, “inflammation”, “disseminated intravascular coagulation”, “trauma”, “surgery”, “infection”, “sepsis”, “pregnancy”, “joint arthroplasty”, “cardiovascular disease”, “acute aortic dissection”, and “coronary artery disease”