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For example, Mll1/2 methylate less than 5% of H3K4me3 in mammals, but were found to be essential for the methylation of Hox loci [5], [127], [128], [129] and in mouse embryonic stem cells Mll2 contributes to H3K4me3 at bivalent (H3K27me3/H3K4me3 positive) gene promoters [129]

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However, these benefits stem largely from NAC's ability to reduce oxidative stress and boost glutathione—which means that highly absorbable glutathione supplementation can offer similar reproductive support by directly addressing oxidative stress at the cellular level