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Preclinical studies have further revealed that nicotine exposure beginning in early adolescence, relative to later adolescence, leads to increased expression of nicotinic acetylcholine receptor in NAc, increased sensitivity to nicotine, and higher rates of nicotine self-administration in adulthood (Kandel, 1975

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however, further large-scale-controlled, multicenter studies are required to support these results.[125] A novel topical hypopigmenting product containing ethyl linoleate, thioctic acid, octadecenedioic acid, lactic acid, and ethylhexyl methoxycinnamate was observed to have a significant skin lightening effect as compared to the control group.[126] 10% solution of zinc sulfate when compared to 4% HQ solution was not found to be as effective as the latter, although the frequency of irritation was significantly higher with HQ.[120] Magnesium-L-ascorbyl-2-phosphate (MAP) is a stable derivative of ascorbic acid, known to inhibit melanin synthesis