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The studies indicate highly constrained steric and conformational requirements for the interaction, which, along with the rapid on-off timing of the effects, is consistent with the involvement of reversible ligand-binding site interactions [52]

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(54) PATHOPHYSIOLOGY OF ALCOHOL AND CIRRHOSIS Acetaldehyde is a metabolite of alcohol that, when it accumulates, produces liver damage as the result of its ability to generate formation of DNA adducts such as sites without purine or pyrimidine (Figure 3)