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Mice with inactivating mutations in the gene coding for the enzyme alcohol dehydrogenase 5 (Adh5) and in the gene coding for the factor Fanconi Anaemia Complementation Group D2 (Fancd2) accumulate FA-DNA adducts and present hematopoietic stem cell attrition, which correlates with genome instability in the hematopoietic compartment 9

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This inconsistency likely comes down to a few factors: The dose used in the study The specific formulation, such as liposomal versus standard oral capsules How long the person took the supplement The person's starting nutritional status This means a short trial run of glutathione may not show much benefit, while a longer, well-managed approach might work differently