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In mice, oral bioavailability was 3.5%, and the oral peak blood concentration was 14.5 ng/mL against a mouse NNMT IC50 of 78 ng/mL — meaning the oral route never reached the concentration that inhibits the target enzyme

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Macrocytic anemia occurs when your body doesn’t have enough normal red blood cells, and can cause symptoms including “muscle weakness and paresthesias” (paresthesias is the technical term for the “pins and needles” feeling on your skin)