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In agreement to this, the corresponding close homologs (LIMK2 and ACK1/TNK2) that do not have a cysteine in their P-loop were less inhibited (remaining activity: 85% and 80%, respectively)

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Future studies should leverage various techniques, including omics, imaging, and animal models, to investigate the molecular mechanisms of ionizing radiation-induced ferroptosis in the lens and clarify the role of ferroptosis at different stages of radiation-induced cataract development

or prevent any disease.