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In the intestinal epithelium, NF-κB activation via Inhibitor of Nuclear Factor Kappa B Kinase Subunit Beta (IKKβ) promotes transcription of anti-apoptotic genes such as B-cell Lymphoma 2 (Bcl-2) and X-linked Inhibitor of Apoptosis (XIAP), and suppression of p53-PUMA signaling, limiting epithelial apoptosis and maintaining barrier integrity