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Moreover, women who have both obesity and PCOS exhibit a greater level of insulin resistance in comparison to obese persons who do not have PCOS [53]

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Morgado-Carrasco et al., 2022): 3.1 Improper melanocytes activity and accumulation of melanocytes in the dermis and epidermis layers Although increase in melanin levels in melasma patients is a known fact, however, the exact mechanism of this increment is not fully understood