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While excellent recent reviews have summarized mtDAMP biology in sterile inflammation and systemic diseases (30–32), the present work offers distinctive contributions tailored to the perioperative context by establishing the perioperative continuum—from preoperative optimization through intraoperative IR injury to postoperative recovery—as a unified temporal framework for mitochondrial intervention, moving beyond isolated disease models

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When I had the loading doses (6 Injections over 2 weeks) I felt completely wiped out half way through