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These results were in line with a C57BL/6 J APP/PS1 transgenic mouse model, in which vitamin A deprivation leads to an increase in the cortex of pTau in addition to an increase in Aβ40 and Aβ42 in the cortex and in the expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) gene transcript (27)

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Nat Rev Endocrinol (2021) 17(8):497–510