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Van Moh F, Vetter J and Lai HH: Comparison of urologic and non-urologic presentation in interstitial cystitis/bladder pain syndrome patients with and without hunner lesions

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ROS can activate MAPKs, leading to the phosphorylation and activation of downstream targets, for instance, AP-1 and NF- κ B transcription factors, which in turn regulate the expression of genes involved in cell survival, proliferation, and apoptosis [44]