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However, in another study reporting administration of NR or the CD38 inhibitor GSK987A to mdx mice for 20 weeks 267 , treated mice with the CD38 inhibitor showed increased NAD + levels in muscle tissue, but no improvement was found in muscle function after treatment with either the inhibitor or with NR

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Research in animal models has shown sustained reductions in body weight gain and increased fat oxidation over extended treatment periods, with individual results varying considerably based on adherence to diet and exercise protocols alongside peptide use