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PET imaging reveals microglia activation in the SN before motor symptoms appear, while peripheral immune cells (e.g., CD8 + T cells and monocytes) can infiltrate the central nervous system through compromised BBB (63)

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A gradient program was performed with a combination of 0.1% acetic acid in water (mobile phase A) and acetonitrile (mobile phase B), and was performed with a flow rate of 0.4 mL/min, starting with an initial composition of 25% B