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PLATELET-RICH PLASMA The term PRP was introduced in the 1970s to describe the autologous preparations and enrichment of platelets from plasma concentrate.[6] Platelets also known as thrombocytes are produced from megakaryocytes in mammalian bone marrow.[7] They form a first line of cellular defense response following damage to vascular and tissue integrity and play a crucial role in homeostasis, innate immunity, angiogenesis and wound healing.[8,9,10] Under normal conditions, the typical blood samples contain approximately 94% of red blood cells (RBCs), 6% of platelets and 1% of white blood cells