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Nrf2 suppresses oxidative stress and inflammation in APP knock-in alzheimer’s disease model mice

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Antioxidant enzymes, including catalase (CAT), superoxide dismutase, glutathione peroxidase (GPx) and glutathione reductase (GR), are the main parts of antioxidant defense system that deactivate reactive radicals mainly by reducing them to a more stable compound (Reference Krishnamurthy and Wadhwani20)