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In diet-induced obesity models: These findings suggest that the compound’s effects are driven by metabolic reprogramming rather than appetite suppression, making it highly relevant for research into lipid metabolism and energy utilization

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To illustrate the scale of the net payment adjustments under these proposed policies, the proposed ASM redistribution percentage of 85 percent and an ASM risk level of 9 percent would lead to an estimated net 7.65 percent (that is, 85 percent multiplied by 9 percent) of the Medicare Part B covered professional service payments distributed in the form of payment adjustments to ASM participants and an estimated 1.35 percent (that is, 15 percent multiplied by 9 percent) retained by Medicare We refer readers to the regulatory impact analysis in section VII of this final rule for further discussion on the estimated impacts of these payment adjustments