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In this context, punctate 4-HNE labelling was readily detected throughout the cytosol of oocytes (both GV and MII) but was observed to notably increase in the vicinity of the nuclear envelope of GV oocytes and in association with the meiotic spindle of MII oocytes

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Furthermore, stiffer blood vessels can have increased permeability and become more likely to develop plaque accumulation, which can lead to further complications (82)