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In this research, the expression of GPX4 and SLC7A11 was found to be down-regulated (Figures 5L–O) and the expression of ACSL4 was significantly increased in the cochlea following exposure to PS-NPs (Figures 5L, M)

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Thus, the elimination of the basal flux and low H 2 O 2 levels is performed by GPx and Prx2, since CAT does not work efficiently at low H 2 O 2 levels [60]