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Moreover, more recently a family of proteins called peroxiredoxins has been recognized as catalyzing the reduction of H 2 O 2 by GSH and/or other thiols, but with cysteine in its thiolate form, in their active sites rather than selenium-cysteine (Strange et al., 2000)

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Since spironolactone acts as competitive antagonist at the aldosterone receptors its main clinical use is in the treatment of hyperaldosteronism

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