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→ International: Similar to the U.S., DSIP is not formally approved in Europe, Canada, or Australia

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Yoo and Park, 2001 demonstrated that doxorubicin-loaded micelles formed by PEG-poly(aspartate) block copolymers which enhance tumor accumulation using the permeable and retaining effect (EPR effect), which increased solubility and circulating time in vivo [92]