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Hereditary underexpression of UGT1A1 could be due to variation in the so-called TATA box of the UGT1A1 gene promoter (mostly in Caucasians) or due to mutations in the structural UGT1A1 gene (mostly in Asians) resulting in the development of mild unconjugated hyperbilirubinemia (also known as Gilbert syndrome, OMIM *143500) [150]

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