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Similarly, geraniol (Tavares et al., 2021), a component of essential oil from Cymbopogon winterianus , activates Nrf2, leading to downregulation of pro-oxidant mediators and attenuation of fibrotic progression

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Overall, the role of BCAA metabolism in macrophage polarization is more appropriately defined as an “integrative module of nutrient sensing and energy metabolism,” and its biological output is jointly influenced by dose, metabolic state, inflammatory stage, and the tissue microenvironment

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