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2.3 Modulators Affecting VSMC-derived Foam Cell Formation Formononetin: Formononetin is the primary flavonoid constituent obtained from astragalus and exhibits protective effects against cardiovascular diseases [37, 38] and suppressive effects on the development of AS, such as obesity [39, 40]

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Discovery of 6α-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity