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Considering that ALA treatment reduced GSSG/GSH ratio (despite the nonsignificant increase in GR activity compared to highly upregulated GPx expression), we suggest a possibility that ALA directly assists or partially substitutes for GR function in the GSH−GSSG redox reaction

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Using the relative rates of the major causes of DILI in the DILIN Prospective Study (NCT NCT00345930) and the known rate for amoxicillin/clavulanate (43/100,000) from a population-based study from Iceland, we sought to estimate the incidence of the major causes of idiosyncratic DILI